Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum Disorders Highly Cited Paper

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Title
Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum Disorders
Author(s)
Eunee Lee; Jiseok Lee; Eunjoon Kim
Publication Date
2017-05
Journal
BIOLOGICAL PSYCHIATRY, v.81, no.10, pp.838 - 847
Publisher
ELSEVIER SCIENCE INC
Abstract
Imbalances between excitation and inhibition in synaptic transmission and neural circuits have been implicated in autism spectrum disorders. Excitation and inhibition imbalances are frequently observed in animal models of autism spectrum disorders, and their correction normalizes key autistic-like phenotypes in these animals. These results suggest that excitation and inhibition imbalances may contribute to the development and maintenance of autism spectrum disorders and represent an important therapeutic target. (c) 2016 Society of Biological Psychiatry. This is an open access article under the CC BY-NC-ND license
URI
https://pr.ibs.re.kr/handle/8788114/3886
ISSN
0006-3223
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
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