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Spatiotemporal microstructural white matter changes in diffusion tensor imaging after transient focal ischemic stroke in rats

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Title
Spatiotemporal microstructural white matter changes in diffusion tensor imaging after transient focal ischemic stroke in rats
Author(s)
Won-Beom Jung; Yong Hee Han; Julius Juhyun Chung; Sun Young Chae; Sung Hoon Lee; Geun Ho Im; JiHoon Cha; Jung Hee Lee
Publication Date
2017-06
Journal
NMR IN BIOMEDICINE, v.30, no.6, pp.e3704 -
Publisher
WILEY
Abstract
Structural reorganization in white matter (WM) after stroke is a potential contributor to substitute or to newly establish the functional field on the injured brain in nature. Diffusion tensor imaging (DTI) is an imaging modality that can be used to evaluate damage and recovery within the brain. This method of imaging allows for in vivo assessment of the restricted movements of water molecules in WM and provides a detailed look at structural connectivity in the brain. For longitudinal DTI studies after a stroke, the conventional region of interest method and voxel-based analysis are highly dependent on the user-hypothesis and parameter settings for implementation. In contrast, tract-based spatial statistics (TBSS) allows for reliable voxel-wise analysis via the projection of diffusion-derived parameters onto an alignment-invariant WM skeleton. In this study, spatiotemporal WM changes were examined with DTI-derived parameters (fractional anisotropy, FA; mean diffusivity, MD; axial diffusivity, DA; radial diffusivity, RD) using TBSS 2h to 6weeks after experimental focal ischemic stroke in rats (N=6). FA values remained unchanged 2-4h after the stroke, followed by a continuous decrease in the ipsilesional hemisphere from 24h to 2weeks post-stroke and gradual recovery from the ipsilesional corpus callosum to the external capsule until 6weeks post-stroke. In particular, the fibers in these areas were extended toward the striatum of the ischemic boundary region at 6weeks on tractography. The alterations of the other parameters in the ipsilesional hemisphere showed patterns of a decrease at the early stage, a subsequent pseudo-normalization of MD and DA, a rapid reduction of RD, and a progressive increase in MD, DA and RD with a decreased extent in the injured area at later stages. The findings of this study may reflect the ongoing processes on tissue damage and spontaneous recovery after stroke. © 2017 John Wiley & Sons, Ltd.
URI
https://pr.ibs.re.kr/handle/8788114/3825
ISSN
0952-3480
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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