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뇌과학이미징연구단
뇌과학 이미징 연구단
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Parametric response mapping of dynamic CT: enhanced prediction of survival in hepatocellular carcinoma patients treated with transarterial chemoembolization

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Title
Parametric response mapping of dynamic CT: enhanced prediction of survival in hepatocellular carcinoma patients treated with transarterial chemoembolization
Author(s)
Seung Joon Choi; Jonghoon Kim; Hyung Sik Kim; Hyunjin Park
Publication Date
2017-07
Journal
ABDOMINAL RADIOLOGY, v.42, no.7, pp.1871 - 1879
Publisher
SPRINGER
Abstract
Purpose: The aim of this study was to evaluate the prognostic significance of parametric response mapping (PRM) analysis for hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE). Methods: We recruited 65 HCC patients who underwent TACE. These patients underwent longitudinal multiphasic CT before and after TACE. We applied PRM analysis to the baseline CT before TACE and first/second follow-up CTs. The results of PRM analyses were used to stratify patients into responders and non-responders. Overall survival was compared between the two groups. An independent survival analysis using conventional radiological assessments was performed, and the results were compared with PRM results. Univariate and multivariate analyses were performed to identify clinical factors affecting survival. Results: The PRM analyses demonstrated that the responding group had a median survival of 529 days, while the non-responding group had a median survival of 263 days [hazard ratio (HR) 12.9, p < 0.05 for differences in survival]. The manual analyses indicated median survivals of 491 and 329 days for the responding and non-responding groups, respectively (HR 2.7, p < 0.05). Tumor size, albumin level, and PRM values were found to be significantly related to overall survival after univariate and multivariate analyses. Conclusions: The PRM analysis could be a better predictor of overall survival for patients with HCC undergoing TACE than conventional radiological assessments. (c) Springer Science+Business Media New York 2017
URI
https://pr.ibs.re.kr/handle/8788114/3822
ISSN
2366-004X
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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