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복잡계자기조립연구단
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Interleukin-4 receptor-targeted delivery of Bcl-xL siRNA sensitizes tumors to chemotherapy and inhibits tumor growth

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dc.contributor.authorPadmanaban Guruprasath-
dc.contributor.authorJihoon Kim-
dc.contributor.authorGowri Rangaswamy Gunassekaran-
dc.contributor.authorLianhua Chi-
dc.contributor.authorSoyoun Kim-
dc.contributor.authorRang-Woon Park-
dc.contributor.authorSang-Hyun Kim-
dc.contributor.authorMoon-Chang Baek-
dc.contributor.authorSang Mun Bae-
dc.contributor.authorSang-Yeob Kim-
dc.contributor.authorDong-Kyu Kim-
dc.contributor.authorIn-Kyu Park-
dc.contributor.authorWon-Jong Kim-
dc.contributor.authorByungheon Lee-
dc.date.available2017-09-22T02:10:56Z-
dc.date.created2017-08-29-
dc.date.issued2017-10-
dc.identifier.issn0142-9612-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/3796-
dc.description.abstractIL-4 receptor (IL-4R) is commonly up-regulated on tumor cells, and interactions between the receptor and Interleukin-4 (IL-4) can induce the expression of anti-apoptotic proteins, including Bcl-xL. This contributes to tumor cell survival and their resistance to chemotherapy. In this study, we exploited IL-4R-targeted delivery of Bcl-xL siRNA to IL-4R-expressing tumor cells in order to sensitize them to chemotherapy. To target IL-4R, an IL-4R-binding peptide, IL4RPep-1, was attached to branched polyethyleneimine-superparamagnetic iron oxide nanoparticles (BPEI-SPION). These nanoparticles were then complexed with Bcl-xL-targeting siRNA. IL-4R-targeted BPEI-SPION/Bcl-xL siRNA more efficiently reduced Bcl-xL gene expression and enhanced cytotoxicity of doxorubicin in MDA-MB231 breast tumor cells compared to untargeted BPEI-SPION/Bcl-xL siRNA. The siRNA was released from the complexes after 15 h of incubation at pH 5.5 and was stable in the complexes up to 72 h in the serum. The IL-4R-targeted BPEI-SPION/siRNA was internalized by cells through IL-4R, successfully escaped the endosomes, and was dispersed into the cytoplasm. Near-infrared fluorescence and magnetic resonance imaging demonstrated that in vivo tumor homing and accumulation of IL-4R-targeted BPEI-SPION/siRNA were both higher than untargeted BPEI-SPION/siRNA. The IL-4R-targeted BPEI-SPION/Bcl-xL siRNA, in combination with doxorubicin, significantly inhibited tumor growth in mice compared to untargeted BPEI-SPION/Bcl-xL siRNA. These results suggest that the IL-4R-targeted delivery of Bcl-xL siRNA to IL-4R-expressing tumors can sensitize tumors to chemotherapy and enhance the efficacy of anti-tumor therapeutics. © 2017 Elsevier Ltd. All rights reserved.-
dc.description.uri1-
dc.language영어-
dc.publisherELSEVIER SCI LTD-
dc.subjectBcl-xL-
dc.subjectBPEI-SPION-
dc.subjectChemotherapy-
dc.subjectIL-4R-
dc.subjectsiRNA-
dc.titleInterleukin-4 receptor-targeted delivery of Bcl-xL siRNA sensitizes tumors to chemotherapy and inhibits tumor growth-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000408178600009-
dc.identifier.scopusid2-s2.0-85024363540-
dc.identifier.rimsid60036ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorJihoon Kim-
dc.contributor.affiliatedAuthorWon-Jong Kim-
dc.identifier.doi10.1016/j.biomaterials.2017.07.024-
dc.identifier.bibliographicCitationBIOMATERIALS, v.142, pp.101 - 111-
dc.citation.titleBIOMATERIALS-
dc.citation.volume142-
dc.citation.startPage101-
dc.citation.endPage111-
dc.date.scptcdate2018-10-01-
dc.description.wostc6-
dc.description.scptc6-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordAuthorBcl-xL-
dc.subject.keywordAuthorBPEI-SPION-
dc.subject.keywordAuthorChemotherapy-
dc.subject.keywordAuthorIL-4R-
dc.subject.keywordAuthorsiRNA-
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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