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뇌과학이미징연구단
뇌과학 이미징 연구단
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Structural and functional connectional fingerprints in mild cognitive impairment and Alzheimer's disease patients

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Title
Structural and functional connectional fingerprints in mild cognitive impairment and Alzheimer's disease patients
Author(s)
Seong-Jin Son; Jonghoon Kim; Hyunjin Park
Publication Date
2017-03
Journal
PLOS ONE, v.12, no.3, pp.1 - 14
Publisher
PUBLIC LIBRARY SCIENCE
Abstract
Regional volume atrophy and functional degeneration are key imaging hallmarks of Alzheimer's disease (AD) in structural and functional magnetic resonance imaging (MRI), respectively. We jointly explored regional volume atrophy and functional connectivity to better characterize neuroimaging data of AD and mild cognitive impairment (MCI). All data were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. We compared regional volume atrophy and functional connectivity in 10 subcortical regions using structural MRI and resting-state functional MRI (rs-fMRI). Neuroimaging data of normal controls (NC) (n = 35), MCI (n = 40), and AD (n = 30) were compared. Significant differences of regional volumes and functional connectivity measures between groups were assessed using permutation tests in 10 regions. The regional volume atrophy and functional connectivity of identified regions were used as features for the random forest classifier to distinguish among three groups. The features of the identified regions were also regarded as connectional fingerprints that could distinctively separate a given group from the others. We identified a few regions with distinctive regional atrophy and functional connectivity patterns for NC, MCI, and AD groups. A three label classifier using the information of regional volume atrophy and functional connectivity of identified regions achieved classification accuracy of 53.33% to distinguish among NC, MCI, and AD. We identified distinctive regional atrophy and functional connectivity patterns that could be regarded as a connectional fingerprint. © 2017 Son et al.
URI
http://pr.ibs.re.kr/handle/8788114/3755
DOI
10.1371/journal.pone.0173426
ISSN
1932-6203
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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