The Use of Ammonia as an Ultimate Amino Source in the Transition Metal-Catalyzed C-H Amination

Abstract

The development of efficient and elective transition metal catalyst systems enabling a direct C-H amination of hydrocarbons using ammonia is highly desirable considering the fact that ammonia is the most readily available nitrogen source. It is anticipated that a new mechanistic scaffold distinct from the currently applicable ones will guide this research eventually to have broad applicability in synthetic methodology, medicinal chemistry, and materials science. © 2017 American Chemical Society