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식물 노화·수명 연구단
식물 노화·수명 연구단
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RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

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Title
RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans
Author(s)
Heehwa G. Son; Mihwa Seo; Seokjin Ham; Wooseon Hwang; Dongyeop Lee; Seon Woo A. An; Murat Artan; Keunhee Seo; Rachel Kaletsky; Rachel N. Arey; Youngjae Ryu; Chang Man Ha; Yoon Ki Kim; Coleen T. Murphy; Tae-Young Roh; Hong Gil Nam; Seung-Jae V. Lee
Publication Date
2017-03
Journal
NATURE COMMUNICATIONS, v.8, no., pp.14749 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Long-lived organisms often feature more stringent protein and DNA quality control. However, whether RNA quality control mechanisms, such as nonsense-mediated mRNA decay (NMD), which degrades both abnormal as well as some normal transcripts, have a role in organismal aging remains unexplored. Here we show that NMD mediates longevity in C. elegans strains with mutations in daf-2/insulin/insulin-like growth factor 1 receptor. We find that daf-2 mutants display enhanced NMD activity and reduced levels of potentially aberrant transcripts. NMD components, including smg-2/UPF1, are required to achieve the longevity of several long-lived mutants, including daf-2 mutant worms. NMD in the nervous system of the animals is particularly important for RNA quality control to promote longevity. Furthermore, we find that downregulation of yars-2/tyrosyl-tRNA synthetase, an NMD target transcript, by daf-2 mutations contributes to longevity. We propose that NMD-mediated RNA surveillance is a crucial quality control process that contributes to longevity conferred by daf-2 mutations. © The Author(s) 2017
URI
https://pr.ibs.re.kr/handle/8788114/3746
ISSN
2041-1723
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
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