BROWSE

Related Scientist

Researcher

뇌과학이미징연구단
뇌과학 이미징 연구단
more info

An indirect method for in vivo T-2 mapping of [1-C-13] pyruvate using hyperpolarized C-13 CSI

Cited 1 time in webofscience Cited 0 time in scopus
85 Viewed 6 Downloaded
Title
An indirect method for in vivo T-2 mapping of [1-C-13] pyruvate using hyperpolarized C-13 CSI
Author(s)
Eunhae Joe; Hansol Lee; Joonsung Lee; Seungwook Yang; Young‐Suk Choi; Eunkyung Wang; Ho‐Taek Song; Dong‐Hyun Kim
Publication Date
2017-05
Journal
NMR IN BIOMEDICINE, v.30, no.5, pp.1 - 8
Publisher
WILEY-BLACKWELL
Abstract
An indirect method for in vivo T-2 mapping of C-13-labeled metabolites using T-2 and T-2* information of water protons obtained a priori is proposed. The T-2 values of C-13 metabolites are inferred using the relationship to T-2 of coexisting H-1 and the T-2* of C-13 metabolites, which is measured using routine hyperpolarized C-13 CSI data. The concept is verified with phantom studies. Simulations were performed to evaluate the extent of T-2 estimation accuracy due to errors in the other measurements. Also, bias in the C-13 T-2* estimation from the C-13 CSI data was studied. In vivo experiments were performed from the brains of normal rats and a rat with C6 glioma. Simulation results indicate that the proposed method provides accurate and unbiased C-13 T-2 values within typical experimental settings. The in vivo studies found that the estimated T-2 of [1-C-13] pyruvate using the indirect method was longer in tumor than in normal tissues and gave values similar to previous reports. This method can estimate localized T-2 relaxation times from multiple voxels using conventional hyperpolarized C-13 CSI and can potentially be used with time resolved fast CSI. Copyright © 2017 John Wiley & Sons, Ltd.
URI
https://pr.ibs.re.kr/handle/8788114/3707
ISSN
0952-3480
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
Files in This Item:
17_이준성_An indirect method for in vivo T-2 mapping...pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse