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뇌과학이미징연구단
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Indirect Pathway of Caudal Basal Ganglia for Rejection of Valueless Visual Objects

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Title
Indirect Pathway of Caudal Basal Ganglia for Rejection of Valueless Visual Objects
Author(s)
Hyoung F. Kim; Hidetoshi Amita; Okihide Hikosaka
Publication Date
2017-05
Journal
NEURON, v.94, no.4, pp.920 - 930
Publisher
CELL PRESS
Abstract
The striatum controls behavior in two ways: facilitation and suppression through the direct and indirect pathways, respectively. However, it is still unclear what information is processed in these pathways. To address this question, we studied two pathways originating from the primate caudate tail (CDt). We found that the CDt innervated the caudal-dorsal-lateral part of the substantia nigra pars reticulata (cdlSNr), directly or indirectly through the caudal-ventral part of the globus pallidus externus (cvGPe). Notably, cvGPe neurons receiving inputs from the CDt were mostly visual neurons that encoded stable reward values of visual objects based on long-past experiences. Their dominant response was inhibition by valueless objects, which generated disinhibition of cdlSNr neurons and inhibition of superior colliculus neurons. Our data suggest that low-value signals are sent by the CDt-indirect pathway to suppress saccades to valueless objects, whereas high-value signals are sent by the CDt-direct pathway to facilitate saccades to valuable objects. (c) 2017 Elsevier Inc.
URI
https://pr.ibs.re.kr/handle/8788114/3695
ISSN
0896-6273
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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