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Functional manganese dioxide nanosheet for targeted photodynamic therapy and bioimaging in vitro and in vivo

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Title
Functional manganese dioxide nanosheet for targeted photodynamic therapy and bioimaging in vitro and in vivo
Author(s)
Seongchan Kim; Seong Min Ahn; Ji-Seon Lee; Tae Shik Kim; Dal-Hee Min
Publication Date
2017-06
Journal
2D MATERIALS, v.4, no.2, pp.025069 -
Publisher
IOP PUBLISHING LTD
Abstract
Photodynamic therapy (PDT) has been widely studied as a promising non-invasive therapeutic strategy for the treatment of cancer. However, the poor solubility of photosensitizer (PS) in aqueous solution and inefficient cell-penetrating capability have limited the target-specific PDT. Herein, we develop a novel targeted photodynamic therapeutic and bioimaging system based on folic acid (FA)-conjugated MnO2 (FA-MnO2) nanosheet as a new carrier of PS, zinc phthalocyanine (ZnPc). ZnPc loaded FA-MnO2 nanosheet (FA-MnO2/ZnPc) complex is successfully formed by electrostatic interaction and coordination. We find that FA-MnO2/ZnPc complex exhibits excellent targeted delivery of ZnPc into folate receptor positive cancer cells and the ZnPc is released out from the complex via endogenous glutathione (GSH) stimulus, facilitating simultaneous bioimaging and targeted PDT by singlet oxygen (SO) generation upon light irradiation, showing high efficacy with only one tenth of conventional PS dosage in vitro and in vivo. © 2017 IOP Publishing Ltd
URI
https://pr.ibs.re.kr/handle/8788114/3686
ISSN
2053-1583
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
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