BROWSE

Related Scientist

Researcher

고규영
혈관 연구단
more info

Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

Cited 6 time in webofscience Cited 0 time in scopus
360 Viewed 84 Downloaded
Title
Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII
Author(s)
Chu M.; Li T.; Shen B.; Cao X.; Zhong H.; Zhang L.; Zhou F.; Ma W.; Jiang H.; Xie P.; Liu Z.; Dong N.; Xu Y.; Zhao Y.; Xu G.; Lu P.; Luo J.; Wu Q.; Alitalo K.; Gou Young Koh; Adams R.H.; He Y.
Publication Date
2016-12
Journal
ELIFE, v.5, no., pp.e21032 -
Publisher
ELIFE SCIENCES PUBLICATIONS LTD
Abstract
Mechanisms underlying the vein development remain largely unknown. Tie2 signaling mediates endothelial cell (EC) survival and vascular maturation and its activating mutations are linked to venous malformations. Here we show that vein formation are disrupted in mouse skin and mesentery when Tie2 signals are diminished by targeted deletion of Tek either ubiquitously or specifically in embryonic ECs. Postnatal Tie2 attenuation resulted in the degeneration of newly formed veins followed by the formation of haemangioma-like vascular tufts in retina and venous tortuosity. Mechanistically, Tie2 insufficiency compromised venous EC identity, as indicated by a significant decrease of COUP-TFII protein level, a key regulator in venogenesis. Consistently, angiopoietin-1 stimulation increased COUP-TFII in cultured ECs, while Tie2 knockdown or blockade of Tie2 downstream PI3K/Akt pathway reduced COUP-TFII which could be reverted by the proteasome inhibition. Together, our results imply that Tie2 is essential for venous specification and maintenance via Akt mediated stabilization of COUP-TFII. © Chu et al
URI
http://pr.ibs.re.kr/handle/8788114/3634
DOI
10.7554/eLife.21032
ISSN
2050-084X
Appears in Collections:
Center for Cardiovascular Research(혈관 연구단) > Journal Papers (저널논문)
Files in This Item:
혈관연구단-elife-21032-v2.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse