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Generation of PDGFRα+ Cardioblasts from Pluripotent Stem Cells

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Title
Generation of PDGFRα+ Cardioblasts from Pluripotent Stem Cells
Author(s)
Hong S.P.; Sukhyun Song; Cho S.W.; Lee S.; Koh B.I.; Hosung Bae; Kyun Hoo Kim; Jin-Sung Park; Do H.-S.; Im I.; Heo H.J.; Ko T.H.; Park J.-H.; Youm J.B.; Kim S.-J.; Kim I.; Han J.; Han Y.-M.; Gou Young Koh
Publication Date
2017-02
Journal
SCIENTIFIC REPORTS, v.7, no., pp.41840 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Isolating actively proliferating cardioblasts is the first crucial step for cardiac regeneration through cell implantation. However, the origin and identity of putative cardioblasts are still unclear. Here, we uncover a novel class of cardiac lineage cells, PDGFRα + Flk1 cardioblasts (PCBs), from mouse and human pluripotent stem cells induced using CsAYTE, a combination of the small molecules Cyclosporin A, the rho-associated coiled-coil kinase inhibitor Y27632, the antioxidant Trolox, and the ALK5 inhibitor EW7197. This novel population of actively proliferating cells is cardiac lineage-committed but in a morphologically and functionally immature state compared to mature cardiomyocytes. Most important, most of CsAYTE-induced PCBs spontaneously differentiated into functional αMHC + cardiomyocytes (M + CMs) and could be a potential cellular resource for cardiac regeneration. © The Author(s) 2017
URI
http://pr.ibs.re.kr/handle/8788114/3629
DOI
10.1038/srep41840
ISSN
2045-2322
Appears in Collections:
Center for Cardiovascular Research(혈관 연구단) > Journal Papers (저널논문)
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