BROWSE

Related Scientist

Researcher

정희정
식물 노화·수명 연구단
more info

Characterization of developmental defects in the forebrain resulting from hyperactivated mTOR signaling by integrative analysis of transcriptomic and proteomic data

Cited 0 time in webofscience Cited 0 time in scopus
299 Viewed 68 Downloaded
Title
Characterization of developmental defects in the forebrain resulting from hyperactivated mTOR signaling by integrative analysis of transcriptomic and proteomic data
Author(s)
Shin, J; Kim, M; Hee-Jung Jung; Cha, HL; Suh-Kim, H; Sanghyun Ahn; Jaehoon Jung; YounAh Kim; Jun, Y; Lee, S; Daehee Hwang; Jaesung Kim
Publication Date
2017-06
Journal
SCIENTIFIC REPORTS, v.7, no.1, pp.2826 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Hyperactivated mTOR signaling in the developing brain has been implicated in multiple forms of pathology including tuberous sclerosis complex (TSC). To date, various phenotypic defects such as cortical lamination irregularity, subependymal nodule formation, dysmorphic astrocyte differentiation and dendritic malformation have been described for patients and animal models. However, downstream networks affected in the developing brain by hyperactivated mTOR signaling have yet to be characterized. Here, we present an integrated analysis of transcriptomes and proteomes generated from wild-type and Tsc1/Emx1-Cre forebrains. This led to comprehensive lists of genes and proteins whose expression levels were altered by hyperactivated mTOR signaling. Further incorporation of TSC patient data followed by functional enrichment and network analyses pointed to changes in molecular components and cellular processes associated with neuronal differentiation and morphogenesis as the key downstream events underlying developmental and morphological defects in TSC. Our results provide novel and fundamental molecular bases for understanding hyperactivated mTOR signaling-induced brain defects which can in turn facilitate identification of potential diagnostic markers and therapeutic targets for mTOR signaling-related neurological disorders. © The Author(s) 2017
URI
http://pr.ibs.re.kr/handle/8788114/3617
DOI
10.1038/s41598-017-02842-6
ISSN
2045-2322
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
Files in This Item:
Characterization of developmental defects in the forebrain.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse