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General rules for functional microRNA targeting

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Title
General rules for functional microRNA targeting
Author(s)
Doyeon Kim; You Me Sung; Jinman Park; Sukjun Kim; Jongkyu Kim; Junhee Park; Haeok Ha; Jung Yoon Bae; SoHui Kim; Daehyun Baek
Publication Date
2016-12
Journal
NATURE GENETICS, v.48, no.12, pp.1517 - 1526
Publisher
NATURE PUBLISHING GROUP
Abstract
The functional rules for microRNA (miRNA) targeting remain controversial despite their biological importance because only a small fraction of distinct interactions, called site types, have been examined among an astronomical number of site types that can occur between miRNAs and their target mRNAs. To systematically discover functional site types and to evaluate the contradicting rules reported previously, we used large-scale transcriptome data and statistically examined whether each of approximately 2 billion site types is enriched in differentially downregulated mRNAs responding to overexpressed miRNAs. Accordingly, we identified seven non-canonical functional site types, most of which are novel, in addition to four canonical site types, while also removing numerous false positives reported by previous studies. Extensive experimental validation and significantly elevated 3′ UTR sequence conservation indicate that these non-canonical site types may have biologically relevant roles. Our expanded catalog of functional site types suggests that the gene regulatory network controlled by miRNAs may be far more complex than currently understood. © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/3568
ISSN
1061-4036
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
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