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Imaging Single-mRNA localization and translation in live neurons

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Title
Imaging Single-mRNA localization and translation in live neurons
Author(s)
Lee B.H.; Bae S.-W.; Shim J.J.; Sung Young Park; Park H.Y.
Publication Date
2016-12
Journal
MOLECULES AND CELLS, v.39, no.12, pp.841 - 846
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Abstract
Local protein synthesis mediates precise spatio-temporal regulation of gene expression for neuronal functions such as long-term plasticity, axon guidance and regeneration. To reveal the underlying mechanisms of local translation, it is crucial to understand mRNA transport, localization and translation in live neurons. Among various techniques for mRNA analysis, fluorescence microscopy has been widely used as the most direct method to study localization of mRNA. Live-cell imaging of single RNA molecules is particularly advantageous to dissect the highly heterogeneous and dynamic nature of messenger ribonucleoprotein (mRNP) complexes in neurons. Here, we review recent advances in the study of mRNA localization and translation in live neurons using novel techniques for single-RNA imaging. © The Korean Society for Molecular and Cellular Biology. All rights reserved
URI
https://pr.ibs.re.kr/handle/8788114/3566
ISSN
1016-8478
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
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