Nitrated proteome in human embryonic stem cells

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Title
Nitrated proteome in human embryonic stem cells
Author(s)
Kang J.W.; Daehee Hwang; Kim K.P.
Publication Date
2016-12
Journal
MASS SPECTROMETRY LETTERS, v.7, no.4, pp.85 - 90
Publisher
KOREAN SOC MASS SPECTROMETRY
Abstract
Post-translational modifications (PTMs) of proteins regulate self-renewal and differentiation in embryonic stem cells (ESCs). Nitration of tyrosine residues of proteins in ESCs modulates their downstream pathways, which can affect self-renewal and differentiation. However, protein tyrosine nitration (PTN) in ESCs has been rarely studied. We reviewed 23 nitrated sites in stem cell proteins. Functional enrichment analysis showed that these nitrated proteins are involved in signal transduction, cell adhesion and migration, and cell proliferation in ESCs. Comparison between the nitrated and known phosphorylated sites revealed that 7 nitrated sites had overlapping phosphorylated sites, indicating functional links of PTNs to their associated signaling pathways in ESCs. Therefore, nitrated proteome provides a basis for understanding potential roles of PTN in self-renewal and differentiation of ESCs. © 2016, Korean Society for Mass Spectrometry. All rights reserved
URI
https://pr.ibs.re.kr/handle/8788114/3511
ISSN
2233-4203
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
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