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면역 미생물 공생 연구단
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Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice

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Title
Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice
Author(s)
Si-Young Cho; Juewon Kim; Ji Hae Lee; Ji Hyun Sim; Dong-Hyun Cho; Il-Hong Bae; Hyunbok Lee; Min A. Seol; Hyun Mu Shin; Tae-Joo Kim; Dae-Yong Kim; Su-Hyung Lee; Song Seok Shin; Sin-Hyeog lm; Hang-Rae Kim
Publication Date
2016-12
Journal
SCIENTIFIC REPORTS, v.6, no., pp.39026 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Age-associated immunological dysfunction (immunosenescence) is closely linked to perturbation of the gut microbiota. Here, we investigated whether syringaresinol (SYR), a polyphenolic lignan, modulates immune aging and the gut microbiota associated with this effect in middle-aged mice. Compared with age-matched control mice, SYR treatment delayed immunosenescence by enhancing the numbers of total CD3+ T cells and naïve T cells. SYR treatment induced the expression of Bim as well as activation of FOXO3 in Foxp3+ regulatory T cells (Tregs). Furthermore, SYR treatment significantly enhanced the Firmicutes/Bacteroidetes ratio compared with that in age-matched controls by increasing beneficial bacteria, Lactobacillus and Bifidobacterium, while reducing the opportunistic pathogenic genus, Akkermansia. In addition, SYR treatment reduced the serum level of lipopolysaccharide-binding protein, an inflammatory marker, and enhanced humoral immunity against influenza vaccination to the level of young control mice. Taken together, these findings suggest that SYR may rejuvenate the immune system through modulation of gut integrity and microbiota diversity as well as composition in middle-aged mice, which may delay the immunosenescence associated with aging. © 2016 The Author(s)
URI
http://pr.ibs.re.kr/handle/8788114/3218
DOI
10.1038/srep39026
ISSN
2045-2322
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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