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CD45-mediated control of TCR tuning in naive and memory CD8(+) T cells

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Title
CD45-mediated control of TCR tuning in naive and memory CD8(+) T cells
Author(s)
Jae-Ho Cho; Hee-Ok Kim; Young-Jun Ju; Yoon-Chul Kye; Gil-Woo Lee; Sung-Woo Lee; Cheol-Heui Yun; Nunzio Bottini; Kylie Webster; Christopher C. Goodnow; Charles D. Surh; Cecile King; Jonathan Sprent
Publication Date
2016-11
Journal
NATURE COMMUNICATIONS, v.7, no., pp.13373 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Continuous contact with self-major histocompatibility complex (MHC) ligands is essential for survival of naive T cells but not memory cells. This surprising finding implies that T cell subsets may vary in their relative T-cell receptor (TCR) sensitivity. Here we show that in CD8(+) T cells TCR sensitivity correlates inversely with levels of CD5, a marker for strong self-MHC reactivity. We also show that TCR sensitivity is lower in memory CD8(+) T cells than naive cells. In both situations, TCR hypo-responsiveness applies only to short-term TCR signalling events and not to proliferation, and correlates directly with increased expression of a phosphatase, CD45 and reciprocal decreased expression of activated LCK. Inhibition by high CD45 on CD8(+) T cells may protect against overt TCR auto-MHC reactivity, while enhanced sensitivity to cytokines ensures strong responses to foreign antigens. (c) The Author(s) 2016
URI
http://pr.ibs.re.kr/handle/8788114/3169
DOI
10.1038/ncomms13373
ISSN
2041-1723
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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