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Protein-Induced Pluripotent Stem Cells Ameliorate Cognitive Dysfunction and Reduce Aβ Deposition in a Mouse Model of Alzheimer’s Disease

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Title
Protein-Induced Pluripotent Stem Cells Ameliorate Cognitive Dysfunction and Reduce Aβ Deposition in a Mouse Model of Alzheimer’s Disease
Author(s)
Moon-Yong Cha; Yoo-Wook Kwon; Hyo-Suk Ahn; Hyobin Jeong; Yong Yook Lee; Minho Moon; Sung Hoon Baik; Dong Kyu Ki; Hyundong Song; Eugene C. Yi; Daehee Hwang; Hyo-Soo Kim; Inhee Mook-Jung
Subject
Alzheimer’s disease x Protein-iPSC x 5XFAD mice x Proteomic analysis x Oligodendrocyte
Publication Date
2017-01
Journal
STEM CELLS TRANSLATIONAL MEDICINE, v.6, no.1, pp.293 - 305
Publisher
WILEY
Abstract
Transplantation of stem cells into the brain attenuates functional deficits in the central nervous system via cell replacement, the release of specific neurotransmitters, and the production of neurotrophic factors. To identify patient-specific and safe stem cells for treating Alzheimer’s disease (AD), we generated induced pluripotent stem cells (iPSCs) derived from mouse skin fibroblasts by treating protein extracts of embryonic stem cells. These reprogrammed cells were pluripotent but nontumorigenic. Here, we report that protein-iPSCs differentiated into glial cells and decreased plaque depositions in the 5XFAD transgenic AD mouse model. We also found that transplanted protein-iPSCs mitigated the cognitive dysfunction observed in these mice. Proteomic analysis revealed that oligodendrocyte-related genes were upregulated in brains injected with protein-iPSCs, providing new insights into the potential function of protein-iPSCs. Taken together, our data indicate that protein-iPSCs might be a promising therapeutic approach for AD. ©AlphaMed Press 2016
URI
https://pr.ibs.re.kr/handle/8788114/3163
DOI
10.5966/sctm.2016-0081
ISSN
2157-6564
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > 1. Journal Papers (저널논문)
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