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Factors forming the BRCA1-A complex orchestrate BRCA1 recruitment to the sites of DNA damage

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Title
Factors forming the BRCA1-A complex orchestrate BRCA1 recruitment to the sites of DNA damage
Author(s)
Joonyoung Her; Nam Soo Lee; Yonghwan Kim; Hongtae Kim
Publication Date
2016-07
Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, v.48, no.7, pp.658 - 664
Publisher
OXFORD UNIV PRESS
Abstract
Sustaining genomic integrity is essential for preventing onset of cancers. Therefore, human cells evolve to have refined biological pathways to defend genetic materials from various genomic insults. DNA damage response and DNA repair pathways essential for genome maintenance are accomplished by cooperative executions of multiple factors including breast cancer type 1 susceptibility protein (BRCA1). BRCA1 is initially identified as an altered gene in the hereditary breast cancer patients. Since then, tremendous efforts to understand the functions of BRAC1 reveal that BRCA1 is found in distinct complexes, including BRCA1-A, BRCA1-B, BRCA1-C, and the BRCA1/PALB2/BRCA2 complex, and plays diverse roles in a context-dependent manner. Among the complexes, BRCA1-A is critical for BRCA1 recruitment to the sites of DNA damage. Factors comprising the BRCA1-A include RAP80, CCDC98/Abraxas, BRCC36, BRCC45, BARD1, BRCA1, and MERIT40, a RAP80-associated factor. In this review, we summarize recent findings of the factors that form the BRCA1-A complex. © The Author 2016. Published by Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/3145
ISSN
1672-9145
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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