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Sex-based selectivity of PPARγ regulation in Th1, Th2, and Th17 differentiation

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Title
Sex-based selectivity of PPARγ regulation in Th1, Th2, and Th17 differentiation
Author(s)
Hong-Jai Park; Hyeon-Soo Park; Jae-Ung Lee; Alfred L. M. Bothwell; Je-Min Choi
Publication Date
2016-08
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.17, no.8, pp.UNSP1347 -
Publisher
MDPI AG
Abstract
Peroxisome proliferator-activated receptor gamma (PPARγ) has recently been recognized to regulate adaptive immunity through Th17 differentiation, Treg functions, and TFH responses. However, its role in adaptive immunity and autoimmune disease is still not clear, possibly due to sexual differences. Here, we investigated in vitro treatment study with the PPARγ agonist pioglitazone to compare Th1, Th2, and Th17 differentiation in male and female mouse splenic T cells. Pioglitazone treatment significantly inhibited various effector T cell differentiations including Th1, Th2, and Th17 cells from female naïve T cells, but it selectively reduced IL-17 production in male Th17 differentiation. Interestingly, pioglitazone and estradiol (E2) co-treatment of T cells in males inhibited differentiation of Th1, Th2, and Th17 cells, suggesting a mechanism for the greater sensitivity of PPARγ to ligand treatment in the regulation of effector T cell differentiation in females. Collectively, these results demonstrate that PPAR selectively inhibits Th17 differentiation only in male T cells and modulates Th1, Th2, and Th17 differentiation in female T cells based on different level of estrogen exposure. Accordingly, PPARγ could be an important immune regulator of sexual differences in adaptive immunity. © 2016 by the authors; licensee MDPI, Basel, Switzerland
URI
http://pr.ibs.re.kr/handle/8788114/3135
DOI
10.3390/ijms17081347
ISSN
1422-0067
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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