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Nucleophile sensitivity of Drosophila TRPA1 underlies light-induced feeding deterrence

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Title
Nucleophile sensitivity of Drosophila TRPA1 underlies light-induced feeding deterrence
Author(s)
Du E.J.; Ahn T.J.; Wen X.; Seo D.-W.; Na D.L.; Kwon J.Y.; Myunghwan Choi; Kim H.-W.; Cho H.; Kang K.
Publication Date
2016-09
Journal
ELIFE, v.5, no., pp.e18425 -
Publisher
ELIFE SCIENCES PUBLICATIONS LTD
Abstract
Solar irradiation including ultraviolet (UV) light causes tissue damage by generating reactive free radicals that can be electrophilic or nucleophilic due to unpaired electrons. Little is known about how free radicals induced by natural sunlight are rapidly detected and avoided by animals. We discover that Drosophila Transient Receptor Potential Ankyrin 1 (TRPA1), previously known only as an electrophile receptor, sensitively detects photochemically active sunlight through nucleophile sensitivity. Rapid light-dependent feeding deterrence in Drosophila was mediated only by the TRPA1(A) isoform, despite the TRPA1(A) and TRPA1(B) isoforms having similar electrophile sensitivities. Such isoform dependence re-emerges in the detection of structurally varied nucleophilic compounds and nucleophilicity-accompanying hydrogen peroxide (H2O2). Furthermore, these isoform-dependent mechanisms require a common set of TRPA1(A)-specific residues dispensable for electrophile detection. Collectively, TRPA1(A) rapidly responds to natural sunlight intensities through its nucleophile sensitivity as a receptor of photochemically generated radicals, leading to an acute light-induced behavioral shift in Drosophila. © Du et al This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
URI
http://pr.ibs.re.kr/handle/8788114/3129
ISSN
2050-084X
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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