Genome editing comes of age

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Title
Genome editing comes of age
Author(s)
Jin-Soo Kim
Publication Date
2016-09
Journal
NATURE PROTOCOLS, v.11, no.9, pp.1573 - 1578
Publisher
NATURE PUBLISHING GROUP
Abstract
Genome editing harnesses programmable nucleases to cut and paste genetic information in a targeted manner in living cells and organisms. Here, I review the development of programmable nucleases, including zinc finger nucleases (ZFNs), TAL (transcription-activator-like) effector nucleases (TALENs) and CRISPR (cluster of regularly interspaced palindromic repeats)–Cas9 (CRISPR-associated protein 9) RNA-guided endonucleases (RGENs). I specifically highlight the key advances that set the foundation for the rapid and widespread implementation of CRISPR–Cas9 genome editing approaches that has revolutionized the field. © 2016 Nature America, Inc. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/3119
ISSN
1754-2189
Appears in Collections:
Center for Genome Engineering(유전체 교정 연구단) > Journal Papers (저널논문)
Files in This Item:
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