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Optical lens-microneedle array for percutaneous light delivery

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Title
Optical lens-microneedle array for percutaneous light delivery
Author(s)
Kim, M; An, J; Kim, KS; Myunghwan Choi; Humar, M; Kwok, SJJ; Dai, TH; Yun, SH
Publication Date
2016-10
Journal
BIOMEDICAL OPTICS EXPRESS, v.7, no.10, pp.4220 - 4227
Publisher
OPTICAL SOC AMER
Abstract
The limited penetration depth of light in skin tissues is a practical bottleneck in dermatologic applications of light-induced therapies, including anti-microbial blue light therapy and photodynamic skin cancer therapy. Here, we demonstrate a novel device, termed optical microneedle array (OMNA), for percutaneous light delivery. A prototype device with a 11 by 11 array of needles at a spacing of 1 mm and a length of 1.6 mm was fabricated by press-molding poly-(lactic acid) (PLA) polymers. The device also incorporates a matched microlens array that focuses the light through the needle tips at specific points to achieve an optimal intensity profile in the tissue. In experiments done with bovine tissues, the OMNA enabled us to deliver a total of 7.5% of the input photons at a wavelength of 491 nm, compared to only 0.85% without the device. This 9-fold enhancement of light delivery was close to the prediction of 10.8 dB by ray-tracing simulation and is expected to increase the effective treatment depth of anti-microbial blue light therapy significantly from 1.3 to 2.5 mm in human skin. (C) 2016 Optical Society of Americ
URI
https://pr.ibs.re.kr/handle/8788114/3110
ISSN
2156-7085
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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