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Functional Connectivity of Child and Adolescent Attention Deficit Hyperactivity Disorder Patients: Correlation with IQ

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Title
Functional Connectivity of Child and Adolescent Attention Deficit Hyperactivity Disorder Patients: Correlation with IQ
Author(s)
Bo-yong Park; Jisu Hong; Seung-Hak Lee; Hyunjin Park
Publication Date
2016-11
Journal
FRONTIERS IN HUMAN NEUROSCIENCE, v.10, no., pp.565 -
Publisher
FRONTIERS RES FOUND
Abstract
Attention deficit hyperactivity disorder (ADHD) is a pervasive neuropsychological disorder that affects both children and adolescents. Child and adolescent ADHD patients exhibit different behavioral symptoms such as hyperactivity and impulsivity, but not much connectivity research exists to help explain these differences. We analyzed openly accessible resting-state functional magnetic resonance imaging (rs-fMRI) data on 112 patients (28 child ADHD, 28 adolescent ADHD, 28 child normal control (NC), and 28 adolescent NC). We used group independent component analysis (ICA) and weighted degree values to identify interaction effects of age (child and adolescent) and symptom (ADHD and NC) in brain networks. The frontoparietal network showed significant interaction effects (p = 0.0068). The frontoparietal network is known to be related to hyperactive and impulsive behaviors. Intelligence quotient (IQ) is an important factor in ADHD, and we predicted IQ scores using the results of our connectivity analysis. IQ was predicted using degree centrality values of networks with significant interaction effects of age and symptom. Actual and predicted IQ scores demonstrated significant correlation values, with an error of about 10%. Our study might provide imaging biomarkers for future ADHD and intelligence studies. © 2016 Park, Hong, Lee and Park.
URI
http://pr.ibs.re.kr/handle/8788114/3101
DOI
10.3389/fnhum.2016.00565
ISSN
1662-5161
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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