BROWSE

Related Scientist

kim,seonggi's photo.

kim,seonggi
뇌과학이미징연구단
more info

ITEM VIEW & DOWNLOAD

Glucose metabolism-weighted imaging with chemical exchange-sensitive MRI of 2-deoxyglucose (2DG) in brain: Sensitivity and biological sources

DC Field Value Language
dc.contributor.authorTao Jin-
dc.contributor.authorHunter Mehrens-
dc.contributor.authorPing Wang-
dc.contributor.authorSeong-Gi Kim-
dc.date.available2017-01-02T06:51:22Z-
dc.date.created2016-10-17-
dc.date.issued2016-12-
dc.identifier.issn1053-8119-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/3083-
dc.description.abstractRecent proof-of-principle studies have demonstrated the feasibility of measuring the uptake and metabolism of non-labeled 2-deoxy-D-glucose (2DG) by a chemical exchange-sensitive spin-lock (CESL) MRI approach. In order to gain better understanding of this new approach, we performed dynamic in vivo CESL MRI on healthy rat brains with an intravenous injection of 2DG under various conditions at 9.4 T. For three 2DG doses of 0.25, 0.5 and 1 g/kg, we found that 2DG-CESL signals increased linearly with injection dose at the initial (<20 min) but not the later period (>40 min) suggesting time-dependent differential weightings of 2DG transport and metabolism. Remaining 2DG-CESL studies were performed with 0.25 g/kg 2DG. Since a higher isoflurane level reduces glucose metabolism and increases blood flow, 2DG-CESL was measured under 0.5%, 1.5% and 2.2% isoflurane. The 2DG-CESL signal was reduced at higher isoflurane levels correlating well with the 2DG phosphorylation in the intracellular space. To detect regional heterogeneities of glucose metabolism, 2DG-CESL with 0.33×0.33×1.50 mm3 resolution was obtained, which indeed showed a higher response in the cortex compared to the corpus callosum. Lastly, unlike CESL MRI with the injection of non-transportable mannitol, the 2DG-CESL response decreased with an increased spin-lock pulse power confirming that 2DG-CESL is dominated by chemical exchange processes in the extravascular space. Taken together, our results showed that 2DG-CESL MRI signals mainly indicate glucose transport and metabolism and may be a useful biomarker for metabolic studies of normal and diseased brains. © 2016 Elsevier Inc.-
dc.description.uri1-
dc.language영어-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectCESL-
dc.subjectCEST-
dc.subjectCMRglu-
dc.subjectGlucose metabolism-
dc.subjectGlucose transport-
dc.subjectMRI-
dc.subjectPET-
dc.titleGlucose metabolism-weighted imaging with chemical exchange-sensitive MRI of 2-deoxyglucose (2DG) in brain: Sensitivity and biological sources-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000389683000008-
dc.identifier.scopusid2-s2.0-84988038540-
dc.identifier.rimsid57442ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorSeong-Gi Kim-
dc.identifier.doi10.1016/j.neuroimage.2016.08.040-
dc.identifier.bibliographicCitationNEUROIMAGE, v.143, pp.82 - 90-
dc.citation.titleNEUROIMAGE-
dc.citation.volume143-
dc.citation.startPage82-
dc.citation.endPage90-
dc.date.scptcdate2018-10-01-
dc.description.wostc9-
dc.description.scptc10-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusCEREBRAL-BLOOD-FLOW-
dc.subject.keywordPlusMAGNETIC-RESONANCE SPECTROSCOPY-
dc.subject.keywordPlusPOSITRON-EMISSION-TOMOGRAPHY-
dc.subject.keywordPlusSATURATION-TRANSFER CEST-
dc.subject.keywordPlusNATURAL D-GLUCOSE-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusISOFLURANE ANESTHESIA-
dc.subject.keywordPlusPARKINSONS-DISEASE-
dc.subject.keywordPlus2-DEOXY-D-GLUCOSE-
dc.subject.keywordPlusDEOXYGLUCOSE-
dc.subject.keywordAuthorCMRgIu-
dc.subject.keywordAuthorGlucose transport-
dc.subject.keywordAuthorGlucose metabolism-
dc.subject.keywordAuthorPET-
dc.subject.keywordAuthorMRI-
dc.subject.keywordAuthorCEST-
dc.subject.keywordAuthorCESL-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
Jin_Kim_NI_2016_2DG_CESL (1).pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse