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뇌과학이미징연구단
뇌과학 이미징 연구단
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Cerebral Hemodynamics and Vascular Reactivity in Mild and Severe Ischemic Rodent Middle Cerebral Artery Occlusion Stroke Models

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Title
Cerebral Hemodynamics and Vascular Reactivity in Mild and Severe Ischemic Rodent Middle Cerebral Artery Occlusion Stroke Models
Author(s)
Jeongeun Sim; Areum Jo; Bok-Man Kang; Sohee Lee; Oh Young Bang; Chaejeong Heo; Gil-Ja Jhon; Youngmi Lee; Minah Suh
Publication Date
2016-06
Journal
EXPERIMENTAL NEUROBIOLOGY, v.25, no.3, pp.130 - 138
Publisher
The Korean Society for Brain and Neural Sciences
Abstract
Ischemia can cause decreased cerebral neurovascular coupling, leading to a failure in the autoregulation of cerebral blood flow. This study aims to investigate the effect of varying degrees of ischemia on cerebral hemodynamic reactivity using in vivo realtime optical imaging. We utilized direct cortical stimulation to elicit hyper-excitable neuronal activation, which leads to induced hemodynamic changes in both the normal and middle cerebral artery occlusion (MCAO) ischemic stroke groups. Hemodynamic measurements from optical imaging accurately predict the severity of occlusion in mild and severe MCAO animals. There is neither an increase in cerebral blood volume nor in vessel reactivity in the ipsilateral hemisphere (I.H) of animals with severe MCAO. The pial artery in the contralateral hemisphere (C.H) of the severe MCAO group reacted more slowly than both hemispheres in the normal and mild MCAO groups. In addition, the arterial reactivity of the I.H in the mild MCAO animals was faster than the normal animals. Furthermore, artery reactivity is tightly correlated with histological and behavioral results in the MCAO ischemic group. Thus, in vivo optical imaging may offer a simple and useful tool to assess the degree of ischemia and to understand how cerebral hemodynamics and vascular reactivity are affected by ischemia. © Experimental Neurobiology 2016.
URI
http://pr.ibs.re.kr/handle/8788114/3062
DOI
10.5607/en.2016.25.3.130
ISSN
1226-2560
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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