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면역미생물공생연구단
면역 미생물 공생 연구단
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Lactobacillus pentosus KF340 alleviates house dust mite-induced murine atopic dermatitis via the secretion of IL-10-producing splenic B10 cells

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Title
Lactobacillus pentosus KF340 alleviates house dust mite-induced murine atopic dermatitis via the secretion of IL-10-producing splenic B10 cells
Author(s)
Bae M.-J.; Kim H.-K.; Lim S.; Lee S.-Y.; Shin H.S.; Jung-Eun Kim; Sin-Hyeog Im; Kim S.
Publication Date
2016-10
Journal
JOURNAL OF FUNCTIONAL FOODS, v.26, no., pp.258 - 267
Publisher
ELSEVIER SCIENCE BV
Abstract
It has been reported that certain LAB isolated from fermented foods are effective suppressors of allergic symptoms. In the present study, the immunomodulatory effects of Lactobacillus pentosus KF340 (LPKF340), originally derived from a traditional fermented Korean food made mainly of cabbage or radish, were tested in a mouse model of allergic atopic dermatitis (AD). Prior treatment with LPKF340 could effectively alleviated pathologic AD symptoms induced by dust mite extract, including oedema and erythema, and decreased lymphocyte infiltration into the inflamed region. In the LPKF340-fed group, the level of allergic cytokine, IL-4, was reduced, while that of anti-inflammatory IL-10 was increased. It was found that splenic regulatory B10 cells were stimulated to produce IL-10 by dendritic cells (DCs) of Peyer's patch. This was dependent on the activity of B cell activating factor in DCs. Taken together, these results suggest that LPKF340 might act as an orally active immunomodulator for allergic AD. © 2016 Elsevier Ltd
URI
https://pr.ibs.re.kr/handle/8788114/2969
ISSN
1756-4646
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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