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Differential responsiveness of innate-like IL-17- and IFN-γ- producing γδ T cells to homeostatic cytokines

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Title
Differential responsiveness of innate-like IL-17- and IFN-γ- producing γδ T cells to homeostatic cytokines
Author(s)
Corpuz T.M.; Stolp J.; Hee-Ok Kim; Pinget G.V.; Gray D.H.D.; Jae-Ho Cho; Sprent J.; Webster K.E.
Publication Date
2016-01
Journal
JOURNAL OF IMMUNOLOGY, v.196, no.2, pp.645 - 654
Publisher
AMER ASSOC IMMUNOLOGISTS
Abstract
γδ T cells respond to molecules upregulated following infection or cellular stress using both TCR and non-TCR molecules. The importance of innate signals versus TCR ligation varies greatly. Both innate-like IL-17-producing γδ T (γδT-17) and IFN-g- producing γδ T (γδT-IFNg) subsets tune the sensitivity of their TCR following thymic development, allowing robust responses to inflammatory cytokines in the periphery. The remaining conventional γδ T cells retain high TCR responsiveness. We determined homeostatic mechanisms that govern these various subsets in the peripheral lymphoid tissues. We found that, although innate-like γδT-17 and γδT-IFNg cells share elements of thymic development, they diverge when it comes to homeostasis. Both exhibit acute sensitivity to cytokines compared with conventional γδ T cells, but they do not monopolize the same cytokine. γδT-17 cells rely exclusively on IL-7 for turnover and survival, aligning them with NKT17 cells; IL-7 ligation triggers proliferation, as well as promotes survival, upregulating Bcl-2 and Bcl-xL. γδT-IFNg cells instead depend heavily on IL-15. They display traits analogous to memory CD8+ T cells and upregulate Bcl-xL and Mcl-1 upon cytokine stimulation. The conventional γδ T cells display low sensitivity to cytokine-alone stimulation and favor IL-7 for their turnover, characteristics reminiscent of naive ab T cells, suggesting that they may also require tonic TCR signaling for population maintenance. These survival constraints suggest that γδ T cell subsets do not directly compete with each other for cytokines, but instead fall into resource niches with other functionally similar lymphocytes. © 2016 by The American Association of Immunologists, Inc Copyright © 2016 by The American Association of Immunologists, Inc. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/2828
ISSN
0022-1767
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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