BROWSE

Related Scientist

Researcher

면역미생물공생연구단
면역 미생물 공생 연구단
more info

SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins

Cited 26 time in webofscience Cited 0 time in scopus
195 Viewed 7 Downloaded
Title
SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins
Author(s)
Park M.-J.; Sheng R.; Silkov A.; Jung D.-J.; Wang Z.-G.; Xin Y.; Kim H.; Thiagarajan-Rosenkranz P.; Song S.; Yoon Y.; Nam W.; Ilshin Kim; Kim E.; Lee D.-G.; Chen Y.; Singaram I.; Wang L.; Myoung Ho Jang; Hwang C.-S.; Honig B.; Ryu S.; Lorieau J.; Kim Y.-M.; Cho W.
Publication Date
2016-04
Journal
MOLECULAR CELL, v.62, no.1, pp.7 - 20
Publisher
CELL PRESS
Abstract
The Src-homology 2 (SH2) domain is a protein interaction domain that directs myriad phosphotyrosine (pY)-signaling pathways. Genome-wide screening of human SH2 domains reveals that ~90% of SH2 domains bind plasma membrane lipids and many have high phosphoinositide specificity. They bind lipids using surface cationic patches separate from pY-binding pockets, thus binding lipids and the pY motif independently. The patches form grooves for specific lipid headgroup recognition or flat surfaces for non-specific membrane binding and both types of interaction are important for cellular function and regulation of SH2 domain-containing proteins. Cellular studies with ZAP70 showed that multiple lipids bind its C-terminal SH2 domain in a spatiotemporally specific manner and thereby exert exquisite spatiotemporal control over its protein binding and signaling activities in T cells. Collectively, this study reveals how lipids control SH2 domain-mediated cellular protein-protein interaction networks and suggest a new strategy for therapeutic modulation of pY-signaling pathways. © 2016 Elsevier Inc.
URI
https://pr.ibs.re.kr/handle/8788114/2825
ISSN
1097-2765
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
Files in This Item:
55466-SH2 domains serve as lipid-binding modules for pTyr-signaling proteins.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse