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Response to Comment on Multiple repressive mechanisms in the hippocampus during memory formation

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Title
Response to Comment on Multiple repressive mechanisms in the hippocampus during memory formation
Author(s)
Jun Cho; Yu N.-K.; V. Narry Kim; Kaang B.-K.
Publication Date
2016-07
Journal
SCIENCE, v.353, no.6298, pp.453 -
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Abstract
Mathew et al. propose that many candidate genes identified in our study may reflect the events in the choroid plexus (ChP) potentially included in hippocampal samples. We reanalyze our data and find that the ChP inclusion is unlikely to affect our major conclusions regarding the basal suppression of translational machinery or the early translational repression (at 5 to 10 minutes). As Mathew et al. examined for a subset of genes at 4 hours, we agree that the late suppression may partly reflect the events in the ChP. Although the precise contribution of anatomical sources remains to be clarified, our behavioral analyses indicate that the late-phase suppression of these genes may contribute to memory formation
URI
https://pr.ibs.re.kr/handle/8788114/2769
ISSN
0036-8075
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
Files in This Item:
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