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면역 미생물 공생 연구단
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The aged lymphoid tissue environment fails to support naive T cell homeostasis

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Title
The aged lymphoid tissue environment fails to support naive T cell homeostasis
Author(s)
Becklund B.R.; Purton J.F.; Ramsey C.; Favre S.; Vogt T.K.; Martin C.E.; Spasova D.S.; Sarkisyan G.; LeRoy E.; Tan J.T.; Wahlus H.; Bondi-Boyd B.; Luther S.A.; Charles D. Surh
Publication Date
2016-08
Journal
SCIENTIFIC REPORTS, v.6, no., pp.30842 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Aging is associated with a gradual loss of naive T cells and a reciprocal increase in the proportion of memory T cells. While reduced thymic output is important, age-dependent changes in factors supporting naive T cells homeostasis may also be involved. Indeed, we noted a dramatic decrease in the ability of aged mice to support survival and homeostatic proliferation of naive T cells. The defect was not due to a reduction in IL-7 expression, but from a combination of changes in the secondary lymphoid environment that impaired naive T cell entry and access to key survival factors. We observed an age-related shift in the expression of homing chemokines and structural deterioration of the stromal network in T cell zones. Treatment with IL-7/mAb complexes can restore naive T cell homeostatic proliferation in aged mice. Our data suggests that homeostatic mechanisms that support the naive T cell pool deteriorate with age © The Author(s) 2016
URI
http://pr.ibs.re.kr/handle/8788114/2768
DOI
10.1038/srep30842
ISSN
2045-2322
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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