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면역미생물공생연구단
면역 미생물 공생 연구단
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Affinity for self antigen selects Treg cells with distinct functional properties.

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Title
Affinity for self antigen selects Treg cells with distinct functional properties.
Author(s)
Wyss L; Stadinski BD; King CG; Schallenberg S; McCarthy NI; Jun Young Lee; Kretschmer K; Terracciano LM; Anderson G; Charles D Surh; Huseby ES; Palmer E
Publication Date
2016-09
Journal
NATURE IMMUNOLOGY, v.17, no.9, pp.1093 - 1103
Publisher
NATURE PUBLISHING GROUP
Abstract
The manner in which regulatory T cells (Treg cells) control lymphocyte homeostasis is not fully understood. We identified two Treg cell populations with differing degrees of self-reactivity and distinct regulatory functions. We found that GITR(hi)PD-1(hi)CD25(hi) (Triple(hi)) Treg cells were highly self-reactive and controlled lympho-proliferation in peripheral lymph nodes. GITR(lo)PD-1(lo)CD25(lo) (Triple(lo)) Treg cells were less self-reactive and limited the development of colitis by promoting the conversion of CD4(+) Tconv cells into induced Treg cells (iTreg cells). Although Foxp3-deficient (Scurfy) mice lacked Treg cells, they contained Triple(hi)-like and Triple(lo)-like CD4(+) T cells zsuper> T cells infiltrated the skin, whereas Scurfy Triple(lo)CD4(+) T cells induced colitis and wasting disease. These findings indicate that the affinity of the T cell antigen receptor for self antigen drives the differentiation of Treg cells into distinct subsets with non-overlapping regulatory activities.
URI
https://pr.ibs.re.kr/handle/8788114/2767
ISSN
1529-2908
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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