Enhanced neuronal activity in the medial prefrontal cortex during social approach behavior

Cited 7 time in webofscience Cited 0 time in scopus
333 Viewed 33 Downloaded
Title
Enhanced neuronal activity in the medial prefrontal cortex during social approach behavior
Author(s)
Eunee Lee; Issac Rhim; Jong Won Lee; Jeong-Wook Ghim; Seungjoon Lee; Eunjoon Kim; Min Whan Jung
Publication Date
2016-06
Journal
JOURNAL OF NEUROSCIENCE, v.36, no.26, pp.6926 - 6936
Publisher
SOC NEUROSCIENCE
Abstract
Although the medial prefrontal cortex (mPFC) is known to play a crucial role in rodent social behavior, little is known aboutmPFCneural correlates of social behavior. In the present study,weexamined single-neuron activity in themPFCof mice performing a modified version of the three-chamber test. We found that a subset of mPFC neurons elevate discharge rates when approaching a stranger mouse but not when approaching an inanimate object or an empty chamber. Our results reveal mPFC neural activity that is correlated with social approach behavior in a widely used social-interaction paradigm. These findings might be helpful for future investigations ofmPFCneural processes underlying social interaction in health and disease. © 2016 The Authors
URI
https://pr.ibs.re.kr/handle/8788114/2762
ISSN
0270-6474
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
2016_130.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse