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Enhanced neuronal activity in the medial prefrontal cortex during social approach behavior

Cited 33 time in webofscience Cited 34 time in scopus
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Title
Enhanced neuronal activity in the medial prefrontal cortex during social approach behavior
Author(s)
Eunee Lee; Issac Rhim; Jong Won Lee; Jeong-Wook Ghim; Seungjoon Lee; Eunjoon Kim; Min Whan Jung
Publication Date
2016-06
Journal
JOURNAL OF NEUROSCIENCE, v.36, no.26, pp.6926 - 6936
Publisher
SOC NEUROSCIENCE
Abstract
Although the medial prefrontal cortex (mPFC) is known to play a crucial role in rodent social behavior, little is known aboutmPFCneural correlates of social behavior. In the present study,weexamined single-neuron activity in themPFCof mice performing a modified version of the three-chamber test. We found that a subset of mPFC neurons elevate discharge rates when approaching a stranger mouse but not when approaching an inanimate object or an empty chamber. Our results reveal mPFC neural activity that is correlated with social approach behavior in a widely used social-interaction paradigm. These findings might be helpful for future investigations ofmPFCneural processes underlying social interaction in health and disease. © 2016 The Authors
URI
https://pr.ibs.re.kr/handle/8788114/2762
DOI
10.1523/JNEUROSCI.0307-16.2016
ISSN
0270-6474
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
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