Enhanced neuronal activity in the medial prefrontal cortex during social approach behavior

DC Field Value Language
dc.contributor.authorEunee Lee-
dc.contributor.authorIssac Rhim-
dc.contributor.authorJong Won Lee-
dc.contributor.authorJeong-Wook Ghim-
dc.contributor.authorSeungjoon Lee-
dc.contributor.authorEunjoon Kim-
dc.contributor.authorMin Whan Jung-
dc.date.available2016-09-01T02:34:21Z-
dc.date.created2016-07-18-
dc.date.issued2016-06-
dc.identifier.issn0270-6474-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/2762-
dc.description.abstractAlthough the medial prefrontal cortex (mPFC) is known to play a crucial role in rodent social behavior, little is known aboutmPFCneural correlates of social behavior. In the present study,weexamined single-neuron activity in themPFCof mice performing a modified version of the three-chamber test. We found that a subset of mPFC neurons elevate discharge rates when approaching a stranger mouse but not when approaching an inanimate object or an empty chamber. Our results reveal mPFC neural activity that is correlated with social approach behavior in a widely used social-interaction paradigm. These findings might be helpful for future investigations ofmPFCneural processes underlying social interaction in health and disease. © 2016 The Authors-
dc.languageENG-
dc.publisherSOC NEUROSCIENCE-
dc.titleEnhanced neuronal activity in the medial prefrontal cortex during social approach behavior-
dc.typeArticle-
dc.type.rimsA-
dc.identifier.wosid000379020200009-
dc.identifier.scopusid2-s2.0-84976480704-
dc.description.wostc7-
dc.date.tcdate2018-10-01-
dc.date.scptcdate2018-10-01-
dc.subject.keywordIn vivo recording-
dc.subject.keywordmPFC-
dc.subject.keywordObject recognition-
dc.subject.keywordSocial interaction-
dc.subject.keywordThree chamber test-
dc.contributor.affiliatedAuthorEunee Lee-
dc.contributor.affiliatedAuthorIssac Rhim-
dc.contributor.affiliatedAuthorJong Won Lee-
dc.contributor.affiliatedAuthorJeong-Wook Ghim-
dc.contributor.affiliatedAuthorEunjoon Kim-
dc.contributor.affiliatedAuthorMin Whan Jung-
dc.identifier.bibliographicCitationJOURNAL OF NEUROSCIENCE, v.36, no.26, pp.6926 - 6936-
dc.description.scptc7-
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
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