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RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans

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Title
RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans
Author(s)
Mihwa Seo; Sangsoon Park; Hong Gil Nam; Seung-Jae V. Lee
Publication Date
2016-07
Journal
CELL CYCLE, v.15, no.14, pp.1821 - 1829
Publisher
LANDES BIOSCIENCE
Abstract
RNA helicases, which unwind RNAs, are essential for RNA metabolism and homeostasis. However, the roles of RNA helicases in specific physiological processes remain poorly understood. We recently reported that an RNA helicase, HEL-1, promotes long lifespan conferred by reduced insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS) in Caenorhabditis elegans. We also showed that HEL-1 induces the expression of longevity genes by physically interacting with Forkhead box O (FOXO) transcription factor. Thus, the HEL-1 RNA helicase appears to regulate lifespan by specifically activating FOXO in IIS. In the current study, we report another longevity-promoting RNA helicase, Suppressor of ACY-4 sterility 1 (SACY-1). SACY-1 contributed to the longevity of daf-2/insulin/IGF-1 receptor mutants. Unlike HEL-1, SACY-1 was also required for the longevity due to mutations in genes involved in non-IIS pathways. Thus, SACY-1 appears to function as a general longevity factor for various signaling pathways, which is different from the specific function of HEL-1. © 2016 Taylor & Francis
URI
https://pr.ibs.re.kr/handle/8788114/2740
ISSN
1538-4101
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
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