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Regulation of Poly(A) Tail and Translation during the Somatic Cell Cycle

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Title
Regulation of Poly(A) Tail and Translation during the Somatic Cell Cycle
Author(s)
Jong-Eun Park; Hyerim Yi; Yoosik Kim; Hyeshik Chang; V. Narry Kim
Publication Date
2016-05
Journal
MOLECULAR CELL, v.62, no.3, pp.462 - 471
Publisher
CELL PRESS
Abstract
Poly(A) tails are critical for mRNA stability and translation. However, recent studies have challenged this view, showing that poly(A) tail length and translation efficiency are decoupled in non-embryonic cells. Using TAIL-seq and ribosome profiling, we investigate poly(A) tail dynamics and translational control in the somatic cell cycle. We find dramatic changes in poly(A) tail lengths of cell-cycle regulatory genes like CDK1, TOP2A, and FBXO5, explaining their translational repression in M phase. We also find that poly(A) tail length is coupled to translation when the poly(A) tail is <20 nucleotides. However, as most genes have >20 nucleotide poly(A) tails, their translation is regulated mainly via poly(A) tail length-independent mechanisms during the cell cycle. Specifically, we find that terminal oligopyrimidine (TOP) tract-containing transcripts escape global translational suppression in M phase and are actively translated. Our quantitative and comprehensive data provide a revised view of translational control in the somatic cell cycle. © 2016 Elsevier Inc.
URI
https://pr.ibs.re.kr/handle/8788114/2660
ISSN
1097-2765
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
Files in This Item:
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