Phospholipase C-β1 hypofunction in the pathogenesis of schizophrenia

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Title
Phospholipase C-β1 hypofunction in the pathogenesis of schizophrenia
Author(s)
Seong-Wook Kim; Taesup Cho; Sukchan Lee
Publication Date
2015-11
Journal
FRONTIERS IN PSYCHIATRY, v.6, no.NOV, pp.159 -
Publisher
FRONTIERS MEDIA SA
Abstract
Schizophrenia is a mental disorder that is characterized by various abnormal symptoms. Previous studies indicate decreased expression of phospholipase C-β1 (PLC-β1) in the brains of patients with schizophrenia. PLC-β1-null (PLC-β1-/-) mice exhibit multiple endophenotypes of schizophrenia. Furthermore, a study of PLC-β1 knockdown in the medial prefrontal cortex of mice has shown a specific behavioral deficit, impaired working memory. These results support the notion that disruption of PLC-β1-linked signaling in the brain is strongly involved in the pathogenesis of schizophrenia. In this review, we broadly investigate recent studies regarding schizophrenia-related behaviors as well as their various clinical and biological correlates in PLC-β1-/- and knockdown mouse models. This will provide a better understanding of the pathological relevance of the altered expression of PLC-β1 in the brains of patients with schizophrenia. Evidence accumulated will shed light on future in-depth studies, possibly in human subjects. © 2015 Kim, Cho and Lee
URI
https://pr.ibs.re.kr/handle/8788114/2632
ISSN
1664-0640
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
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