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뇌과학이미징연구단
뇌과학 이미징 연구단
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Metabolite-selective hyperpolarized C-13 imaging using extended chemical shift displacement at 9.4 T

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Title
Metabolite-selective hyperpolarized C-13 imaging using extended chemical shift displacement at 9.4 T
Author(s)
Seungwook Yang; Joonsung Lee; Eunhae Joe; Hansol Lee; Young-Suk Choi; Jae Mo Park; Daniel Spielman; Ho-Taek Song; Dong-Hyun Kim
Publication Date
2016-05
Journal
MAGNETIC RESONANCE IMAGING, v.34, no.4, pp.535 - 540
Publisher
ELSEVIER SCIENCE INC
Abstract
Purpose: To develop a technique for frequency-selective hyperpolarized C-13 metabolic imaging in ultra-high field strength which exploits the broad spatial chemical shift displacement in providing spectral and spatial selectivity. Methods: The spatial chemical shift displacement caused by the slice-selection gradient was utilized in acquiring metabolite-selective images. Interleaved images of different metabolites were acquired by reversing the polarity of the slice-selection gradient at every repetition time, while using a low-bandwidth radio-frequency excitation pulse to altematingly shift the displaced excitation bands outside the imaging subject Demonstration of this technique is presented using H-1 phantom and in vivo mouse renal hyperpolarized C-13 imaging experiments with conventional chemical shift imaging and fast low-angle shot sequences. Results: From phantom and in vivo mouse studies, the spectral selectivity of the proposed method is readily demonstrated using results of chemical shift spectroscopic imaging, which displayed clearly delineated images of different metabolites. Imaging results using the proposed method without spectral encoding also showed effective separation while also providing high spatial resolution. Conclusion: This method provides a way to acquire spectrally selective hyperpolarized C-13 metabolic images in a simple implementation, and with potential ability to support combination with more elaborate readout methods for faster imaging. (C) 2015 Elsevier Inc. All rights reserved
URI
https://pr.ibs.re.kr/handle/8788114/2569
ISSN
0730-725X
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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