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Bioabsorbable polymer optical waveguides for deep-tissue photomedicine

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Title
Bioabsorbable polymer optical waveguides for deep-tissue photomedicine
Author(s)
Sedat Nizamoglu; Malte C. Gather; Matjaž Humar; Myunghwan Choi; Seonghoon Kim; Ki Su Kim; Sei Kwang Hahn; Giuliano Scarcelli; Mark Randolph; Robert W. Redmond; Seok Hyun Yun
Publication Date
2016-01
Journal
NATURE COMMUNICATIONS, v.7, no., pp.10374 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Advances in photonics have stimulated significant progress in medicine, with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical utility. Here we show implantable light-delivery devices made of bio-derived or biocompatible, and biodegradable polymers. In contrast to conventional optical fibres, which must be removed from the body soon after use, the biodegradable and biocompatible waveguides may be used for long-term light delivery and need not be removed as they are gradually resorbed by the tissue. As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bonding (PTB). Using comb-shaped planar waveguides, we achieve a full thickness ( 410 mm) wound closure of porcine skin, which represents similar to 10-fold extension of the tissue area achieved with conventional PTB. The results point to a new direction in photomedicine for using light in deep tissues.
URI
http://pr.ibs.re.kr/handle/8788114/2558
DOI
10.1038/ncomms10374
ISSN
2041-1723
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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