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The level of autoantibodies targeting eukaryote translation elongation factor 1 α1 and ubiquitin-conjugating enzyme 2L3 in nondiabetic young adults

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Title
The level of autoantibodies targeting eukaryote translation elongation factor 1 α1 and ubiquitin-conjugating enzyme 2L3 in nondiabetic young adults
Author(s)
Kim E.G.; Kwak S.H.; Daehee Hwang; Yi E.C.; Park K.S.; Koo B.K.; Kim K.M.
Publication Date
2016-04
Journal
Diabetes and Metabolism Journal, v.40, no.2, pp.154 - 160
Publisher
대한당뇨병학회
Abstract
Background: The prevalence of novel type 1 diabetes mellitus (T1DM) antibodies targeting eukaryote translation elongation factor 1 alpha 1 autoantibody (EEF1A1-AAb) and ubiquitin-conjugating enzyme 2L3 autoantibody (UBE2L3-AAb) has been shown to be negatively correlated with age in T1DM subjects. Therefore, we aimed to investigate whether age affects the levels of these two antibodies in nondiabetic subjects. Methods: EEF1A1-AAb and UBE2L3-AAb levels in nondiabetic control subjects (n=150) and T1DM subjects (n=101) in various ranges of age (18 to 69 years) were measured using an enzyme-linked immunosorbent assay. The cutoffpoint for the presence of each autoantibody was determined based on control subjects using the formula: [mean absorbance+3×standard deviation]. Results: In nondiabetic subjects, there were no significant correlations between age and EEF1A1-AAb and UBE2L3-AAb levels. However, there was wide variation in EEF1A1-AAb and UBE2L3-AAb levels among control subjects < 40 years old; the prevalence of both EEF1A1-AAb and UBE2L3-AAb in these subjects was 4.4%. When using cutoffpoints determined from the control subjects < 40 years old, the prevalence of both autoantibodies in T1DM subjects was decreased (EEFA1-AAb, 15.8% to 8.9%; UBE2L3-AAb, 10.9% to 7.9%) when compared to the prevalence using the cutoffderived from the totals for control subjects. Conclusion: There was no association between age and EEF1A1-AAb or UBE2L3-AAb levels in nondiabetic subjects. However, the wide variation in EEF1A1-AAb and UBE2L3-AAb levels apparent among the control subjects < 40 years old should be taken into consideration when determining the cutoffreference range for the diagnosis of T1DM. © 2016 Korean Diabetes Association
URI
https://pr.ibs.re.kr/handle/8788114/2521
ISSN
2233-6079
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
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