Copper-Catalyzed Direct Synthesis of 1,2,4-Oxadiazoles from Amides and Organic Nitriles by Oxidative N-O Bond Formation
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Title
- Copper-Catalyzed Direct Synthesis of 1,2,4-Oxadiazoles from Amides and Organic Nitriles by Oxidative N-O Bond Formation
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Author(s)
- Malleswara Rao Kuram; Woo Gyum Kim; Kyungjae Myung; Sung You Hong
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Subject
- Copper, ; Heterocycles, ; 1, 2, 4-Oxadiazoles, ; Homogeneous catalysis, ; Cyclization
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Publication Date
- 2016-01
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Journal
- EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v.2016, no.3, pp.438 - 442
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Publisher
- WILEY-V C H VERLAG GMBH
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Abstract
- Herein, we report the first Cu-catalyzed one-step method for the synthesis of 1,2,4-oxadiazoles from stable, less toxic, and readily available amides and organic nitriles by a rare oxidative N-O bond formation using O-2 as sole oxidant. This method has a broad substrate scope and a good tolerance for diverse functional groups. Moreover, the synthetic utility of this method is highlighted by the synthesis of biologically active 3,5-disubstituted derivatives. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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URI
- https://pr.ibs.re.kr/handle/8788114/2493
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DOI
- 10.1002/ejoc.201501502
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ISSN
- 1434-193X
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Appears in Collections:
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