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뇌과학이미징연구단
뇌과학 이미징 연구단
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Alternating steady state free precession for estimation of current-induced magnetic flux density: A feasibility study

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Title
Alternating steady state free precession for estimation of current-induced magnetic flux density: A feasibility study
Author(s)
Hyunyeol Lee; Jeong, Woo Chul; Kim, Hyung Joong; Woo, Eung Je; Park, Jaeseok
Publication Date
2016-05
Journal
MAGNETIC RESONANCE IN MEDICINE, v.75, no.5, pp.2009 - 2019
Publisher
WILEY-BLACKWELL
Abstract
Purpose: To develop a novel, current-controlled alternating steady-state free precession (SSFP)-based conductivity imaging method and corresponding MR signal models to estimate current-induced magnetic flux density (Bz) and conductivity distribution. Methods: In the proposed method, an SSFP pulse sequence, which is in sync with alternating current pulses, produces dual oscillating steady states while yielding nonlinear relation between signal phase and Bz. A ratiometric signal model between the states was analytically derived using the Bloch equation, wherein Bz was estimated by solving a nonlinear inverse problem for conductivity estimation. A theoretical analysis on the signal-to-noise ratio of Bz was given. Numerical and experimental studies were performed using SSFP-FID and SSFP-ECHO with current pulses positioned either before or after signal encoding to investigate the feasibility of the proposed method in conductivity estimation. Results: Given all SSFP variants herein, SSFP-FID with alternating current pulses applied before signal encoding exhibits the highest Bz signal-to-noise ratio and conductivity contrast. Additionally, compared with conventional conductivity imaging, the proposed method benefits from rapid SSFP acquisition without apparent loss of conductivity contrast. Conclusion: We successfully demonstrated the feasibility of the proposed method in estimating current-induced Bz and conductivity distribution. It can be a promising, rapid imaging strategy for quantitative conductivity imaging. Magn Reson Med 75(5) : 2009-2019. (C) 2015 Wiley Periodicals, Inc.
URI
https://pr.ibs.re.kr/handle/8788114/2478
ISSN
0740-3194
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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