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The short-lived African turquoise killifish: an emerging experimental model for ageing

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Title
The short-lived African turquoise killifish: an emerging experimental model for ageing
Author(s)
Yumi Kim; Hong Gil Nam; Dario Riccardo Valenzano
Publication Date
2016-02
Journal
DISEASE MODELS & MECHANISMS, v.9, no.2, pp.115 - 129
Publisher
COMPANY OF BIOLOGISTS LTD
Abstract
Human ageing is a fundamental biological process that leads to functional decay, increased risk for various diseases and, ultimately, death. Some of the basic biological mechanisms underlying human ageing are shared with other organisms; thus, animal models have been invaluable in providing key mechanistic and molecular insights into the common bases of biological ageing. In this Review, we briefly summarise the major applications of the most commonly used model organisms adopted in ageing research and highlight their relevance in understanding human ageing. We compare the strengths and limitations of different model organisms and discuss in detail an emerging ageing model, the short-lived African turquoise killifish. We review the recent progress made in using the turquoise killifish to study the biology of ageing and discuss potential future applications of this promising animal model. © 2016. Published by The Company of Biologists Ltd | Disease Models & Mechanisms. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
URI
http://pr.ibs.re.kr/handle/8788114/2458
DOI
10.1242/dmm.023226
ISSN
1754-8403
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
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