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면역미생물공생연구단
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Flagellin suppresses experimental asthma by generating regulatory dendritic cells and T cells

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Title
Flagellin suppresses experimental asthma by generating regulatory dendritic cells and T cells
Author(s)
Shim JU; Lee SE; Won Hwang; Changhon Lee; Park JW; Sohn JH; Nam JH; Kim Y; Rhee JH; Sin-Hyeog Im; Koh YI
Publication Date
2016-02
Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, v.137, no.2, pp.426 - 435
Publisher
MOSBY-ELSEVIER
Abstract
Background: Although the hygiene hypothesis suggests that microbial infections could subvert asthma and thus a microbial product might serve as a therapeutic adjuvant for asthma, the relationship between bacterial components and asthma is complex. Recently, low levels of flagellin, the Toll-like receptor (TLR) 5 ligand, have been reported to promote asthma. Objective: We show that a therapeutic dose of flagellin suppresses asthma and that the effect occurs through generating regulatory dendritic cells (rDCs) and regulatory T (Treg) cells. Methods: Ovalbumin (OVA)–induced wild-type and TLR5 knockout asthmatic mice were treated intranasally with a mixture of OVA and 10 mg of a flagellin B (FlaB; of Vibrio vulnificus). OVA/FlaB-treated rDCs were adoptively transferred to mice with OVA-induced asthma. Anti-CD25 mAb was used to deplete Treg cells. A mixture of house dust mite (HDM) and FlaB was used to treat mice with HDM-induced asthma. Blood CD141 monocyte-derived dendritic cells from HDM-sensitive asthmatic patients were treated with FlaB and incubated with autologous CD41 T cells. (c) 2015 American Academy of Allergy, Asthma & Immunology
URI
https://pr.ibs.re.kr/handle/8788114/2393
ISSN
0091-6749
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
Files in This Item:
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