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Inhibition of elongin C promotes longevity and protein homeostasis via HIF-1 in C. elegans

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Title
Inhibition of elongin C promotes longevity and protein homeostasis via HIF-1 in C. elegans
Author(s)
Hwang, W; Artan, M; Seo, M; Lee, D; Hong Gil Nam; Lee, SJV
Publication Date
2015-12
Journal
AGING CELL, v.14, no.6, pp.995 - 1002
Publisher
WILEY-BLACKWELL
Abstract
The transcription factor hypoxia-inducible factor 1 (HIF-1) is crucial for responses to low oxygen and promotes longevity in Caenorhabditis elegans. We previously performed a genomewide RNA interference screen and identified many genes that act as potential negative regulators of HIF-1. Here, we functionally characterized these genes and found several novel genes that affected lifespan. The worm ortholog of elongin C, elc-1, encodes a subunit of E3 ligase and transcription elongation factor. We found that knockdown of elc-1 prolonged lifespan and delayed paralysis caused by impaired protein homeostasis. We further showed that elc-1 RNA interference increased lifespan and protein homeostasis by upregulating HIF-1. The roles of elongin C and HIF-1 are well conserved in eukaryotes. Thus, our study may provide insights into the aging regulatory pathway consisting of elongin C and HIF-1 in complex metazoans. ª 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
URI
http://pr.ibs.re.kr/handle/8788114/2391
DOI
10.1111/acel.12390
ISSN
1474-9718
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
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