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면역 미생물 공생 연구단
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The Probiotic mixture IRT5 ameliorates age-dependent colitis in rats

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Title
The Probiotic mixture IRT5 ameliorates age-dependent colitis in rats
Author(s)
Jeong JJ; Woo JY; Ahn YT; Shim JH; Huh CS; Sin-Hyeog Im; Han MJ; Kim DH
Publication Date
2015-06
Journal
INTERNATIONAL IMMUNOPHARMACOLOGY, v.26, no.2, pp.416 - 422
Publisher
ELSEVIER SCIENCE BV
Abstract
To investigate the anti-inflammatory effect of probiotics, we orally administered IRT5 (1 × 109 CFU/rat) for 8 weeks to aged (16 months-old) Fischer 344 rats, and measured parameters of colitis. The expression levels of the inflammatory markers' inducible NO synthase (iNOS), cyclooxygenase-2 (COX2), tumor necrosis factor (TNF)-α, and interleukin (IL)-1β were higher in the colons of normal aged rats (18 months-old) than in the colons of normal young rats (6months-old). Treatmentwith IRT5 suppressed the age-associated increased expression of iNOS, COX2, TNF-α, and IL-1β, and activation of NF-κB and mitogen-activated protein kinases. In a similar manner, the expression of tight junction proteins in the colon of normal aged ratswas suppressed more potently than in normal young rats, and treatment of aged rats with IRT5 decreased the age-dependent suppression of tight junction proteins ZO-1, occludin, and claudin-1. Treatment with IRT5 suppressed age-associated increases in expressions of senescencemarkers p16 and p53 in the colon of aged rats, but increased age-suppressed expression of SIRT1. However, treatment with IRT5 inhibited age-associated increased myeloperoxidase activity in the colon. In addition, treatment with IRT5 lowered the levels of LPS in intestinal fluid and blood of aged rats, aswell as the reduced concentrations of reactive oxygen species, malondialdehyde, and C-reactive protein in the blood. These findings suggest that IRT5 treatment may suppress age-dependent colitis by inhibiting gut microbiota LPS production. © 2015 Elsevier B.V. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/2352
ISSN
1567-5769
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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