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Multiple repressive mechanisms in the hippocampus during memory formation

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Title
Multiple repressive mechanisms in the hippocampus during memory formation
Author(s)
Jun Cho; Nam-Kyung Yu; Jun-Hyeok Choi; Su-Eon Sim; SukJae Joshua Kang; Chuljung Kwak; Seung-Woo Lee; Ji-il Kim; Dong Il Choi; V. Narry Kim; Bong-Kiun Kaang
Publication Date
2015-10
Journal
SCIENCE, v.350, no.6256, pp.82 - 87
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Abstract
Memory stabilization after learning requires translational and transcriptional regulations in the brain, yet the temporal molecular changes that occur after learning have not been explored at the genomic scale.We used ribosome profiling and RNA sequencing to quantify the translational status and transcript levels in the mouse hippocampus after contextual fear conditioning. We revealed three types of repressive regulations: translational suppression of ribosomal protein-coding genes in the hippocampus, learning-induced early translational repression of specific genes, and late persistent suppression of a subset of genes via inhibition of estrogen receptor 1 (ESR1/ERa) signaling. In behavioral analyses, overexpressing Nrsn1, one of the newly identified genes undergoing rapid translational repression, or activating ESR1 in the hippocampus impaired memory formation. Collectively, this study unveils the yet-unappreciated importance of gene repression mechanisms for memory formation.
URI
https://pr.ibs.re.kr/handle/8788114/2320
ISSN
0036-8075
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
Files in This Item:
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