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DNA methylation and hydroxymethylation in hematologic differentiation and transformation

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Title
DNA methylation and hydroxymethylation in hematologic differentiation and transformation
Author(s)
Ko, M.; Jungeun An; Rao, A.
Publication Date
2015-12
Journal
CURRENT OPINION IN CELL BIOLOGY, v.37, no., pp.91 - 101
Publisher
CURRENT BIOLOGY LTD
Abstract
Maintenance of the balance of DNA methylation and demethylation is fundamental for normal cellular development and function. Members of the Ten-Eleven-Translocation (TET) family proteins are Fe(II)-dependent and 2-oxoglutarate-dependent dioxygenases that catalyze sequential oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and subsequent oxidized derivatives in DNA. In addition to their roles as intermediates in DNA demethylation, these oxidized methylcytosines are novel epigenetic modifications of DNA. DNA methylation and hydroxymethylation profiles are markedly disrupted in a wide range of cancers but how these changes are related to the pathogenesis of cancers is still ambiguous. In this review, we discuss the current understanding of TET protein functions in normal and malignant hematopoietic development and the ongoing questions to be resolved. © 2015 Elsevier Ltd
URI
https://pr.ibs.re.kr/handle/8788114/2210
ISSN
0955-0674
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > Journal Papers (저널논문)
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