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Induction of immune tolerance to dietary antigens

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Title
Induction of immune tolerance to dietary antigens
Author(s)
Kwang Soon Kim; Charles D. Surh
Publication Date
2015
Journal
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, v.850, no., pp.93 - 118
Publisher
SPRINGER-VERLAG BERLIN
Abstract
The intestinal immune system is continuously exposed to massive amounts of diverse antigens derived from both food and intestinal microbes. Immunological tolerance to these enteric antigens is critical for ensuring intestinal and systemic immune homeostasis. Oral tolerance is a specific type of peripheral tolerance induced by the exposure of antigen via the oral route, emphasizing the role of intestinal immune system for preventing unnecessary hypersensitivity reactions to innocuous dietary and microbial antigens. Here, we discuss how dietary antigens are recognized by intestinal immune systems and highlight the role of Foxp3+regulatory CD4+ T cells (Tregs) in establishment of oral tolerance, the tolerogenic features of intestinal dendritic cells that induce development of Foxp3+ Tregs, and the factors that promote development of the intestinal dendritic cells. © 2015, Springer International Publishing Switzerland
URI
https://pr.ibs.re.kr/handle/8788114/2153
ISSN
0065-2598
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
Files in This Item:
15. (2015) Induction of Immune tolerance to dietary Ag_Adv.Exp.Med.Biol_2015.pdfDownload

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